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WHY
ENZYMES?
Enzyme systems constitute an essential component
of life for humans, animals, plants and all microorganisms.
They can only be formed from organic living matter. Enzymes
are required for the proper and normal functioning of every
organ system. They direct, accelerate, modify or retard all
body functions.
Enzymes serve as the body’s labor force
to perform every single function required for our daily activities
and are required to keep us alive. They are responsible for
all of the functions of every organ system in our bodies. At
the same time, they are most important in supporting our body
defenses and immune system to protect us from harmful forces
and specific dangers to our health. The immune system depends
heavily on enzymes to conduct its protective functions.
In addition to our immune and defense systems,
Enzymes are required for our blood and coagulation system, cardiovascular
functions, kidneys, liver, elimination of toxic products, excretion,
reproduction, etc.
When enzyme activity stops, life stops and
the person or organism dies!
WHAT
ARE ENZYMES?
Enzymes are catalysts. They make things work
faster.
WHY
ARE ENZYMES IMPORTANT TO US?
To an amazingly large extent, enzymes are responsible
for our health!
Biochemists have described them as ‘the body’s labor
force’ or ‘the life energy’ of all organisms.
During the past several years there has been
a resurgence of interest on enzymes for medical diagnosis and
treatment, as well as for other uses, based on the development
of new technology.
During the past decade, enzyme usage in diagnostic
tests has increased dramatically in medical practice worldwide.
Even more important, new and highly promising clinical indications
for Systemic Enzyme Treatment are being reported. In addition
to their use for digestive disorders in the United States and
other countries, enzymes are now widely used in the treatment
of various types of blood clots, particularly those causing
heart attacks and occlusions of the veins of the legs, and in
the treatment of several congenital deficiency diseases.
ENZYMES AS BIOLOGICAL RESPONSE MODIFIERS
During the past
few years, medicine has entered a new era in therapy. The emphasis
has been placed in treatment with substances which stimulate,
replace or duplicate the actions of the internal cellular mediators
which our bodies use in conjunction with our immune systems
to protect us from harm. They are substances of biological origin
administered to patients or to a biological system in order
to improve or modify a natural body system response, generally
of the immune function. These agents are collectively called
Biological Response Modifiers or BRM’s.
These biological treatments are increasingly
considered as safe, natural and rational approaches that stimulate
our normal biological responses and defenses. They are purported
simply to help an immune system that has been sluggish or overtaxed
by providing these new immune stimulants or mediator agents
to aid in the fight. The BRM’s are actually
similar to immune mediators in our bodies, or are capable of
boosting our normal immune functions. Thus, it is thought that
they allow the rest of the body defenses to reconstitute themselves
and take over.
The introduction of BRM’s
to modern medicine represents a tremendous advance in treatment
and it can be expected that their use will increase more and
more as we discover ways in which our defenses function. Results
of their use appear most encouraging. These substances work
together with our internal natural body enzymes as immune system
stimulants. Therapeutic enzymes themselves also are considered
to be important Biological Response Modifiers.
BRM’s have used in clinical
trials in a number of (autoimmune) conditions, cancer and HIV
disease. Most of them are of plant, microbial and, to a lesser
extent, animal origin. In addition to therapeutic enzymes, another
important group of BRM’s consists of
substances call colony stimulating factors. These are being
extensively studied at present and used as adjuvants in the
treatment of cancer, Hepatitis C and other diseases in clinical
practice under specific research protocols.
Interferon, another important biological response
modifier, is now available as a prescription medicine. There
are several varieties of interferon which can stimulate the
immune system as well as low down and even stop the growth of
some cancer cells and of some viruses. Interleukins and tumor
necrosis factors and BCG are also BRM’s.
Included as BRM’s are
other substances whose mechanisms of action are poorly understood.
These include BCG and C-Parvum vaccinations, and substances
surrounded by mystique which, despite considerable controversy,
are consistently reported to have distinct beneficial biological
effects. The latter include 1) picibanil, 2) mistletoe, 3) Lentinan
(a unique preparation from Japan) and other substances from
mushrooms called glucans (e.g. “Maitake”), 4) Imuthiol
(a preparation from the Merieux Institute in Paris), 5) vitamins
A, E and C, and 6) Tufoin. According to the published reports
and presentations in BRM conferences, when these agents are
used in combinations they appear to have a beneficial synergistic
effect. Some enzyme preparations in combinations with other
BRM’s have been reported to be superior
to either substance alone.
Current use of Enzymes in medicine
At present, in the United States and worldwide,
certain specific medical enzymes are used legally as ethical
and effective systemic treatments for a number of conditions.
They are approved by the FDA for use in the
treatment of specific diseases where there is general agreement
about their effectiveness. These conditions or illnesses include:
1) cardiovascular disorders; 2) gastrointestinal conditions,
particularly pancreatic insufficiency and related disorders;
3) replacement therapy of specific genetic disorders and deficiencies;
4) cancer treatment; 5) topical debridement of wounds (degradation
of dying or necrotic tissue); and 6) removal of toxic substances
from the blood.
In the United States, the 1993 Physicians Desk
Reference (PDR) lists around 40 enzyme preparations
approved by the FDA for use in this country.
These include preparations for oral, injectable (intravenous
or intramuscular use) or topical administration.
Enzyme treatments for cancer appears highly
promising in medicine. The rational includes blocking with
enzymes the specific amino acids in the serum that are required
by a specific type of cancer.
Enzymes used in United States for topical
treatment of wounds or degradation of dying or necrotic tissue
include the so called debridement, fibrinolytic and collagenolytic
enzyme mixtures. Debridement enzymes generally contain papain,
trypsin, desoxyribounclease or fibrinolysin in various combinations.
Fibrinolytic enzymes contain combinations or the above listed
debridement enzymes as well as casein, lipase, amylase or
protease. Callagenolytic enzymes contain collagenase.
In the U.S., most of the available oral preparations
are either mixtures of enzymes or single enzymes prescribed
primarily for gastrointestinal disorders. A number of enzymes
and enzyme mixtures are also available over-the-counter as
digestive aids.
Similar preparations have been available
in Europe for around 40 years. The most frequently prescribed
enzyme medications are the various proteolytic or hydrolytic
enzyme mixtures. These include the original enzyme mixture
developed in New York City by Drs. Wolf and Benitez. They
were first manufactured and distributed worldwide by MUCOS
pharma, Germany. These orally administered enzymes are used
for the treatment of inflammatory and other conditions.
These Enzymes preparations are being manufactured
& marketed by Pacific Pharmaceuticals in Pakistan at the
state of the art manufacturing facilit
Wobenzym®
N supports the body’s own immune system,
helps in chronic inflammatory diseases and promotes healthy
blood flow.
Phlogenzym®
Clinical studies proved the combination of the enzymes trypsin
and bromelain together with the flavonoid rutoside to be effective
in the treatment of traumatic sports injuries, degenerative
inflammatory joint diseases, humeroscapular periarthritis, Hepatitis
C & other Immune disorders.
WOBE-MUGOS®E
The combination of papain, chymotrypsin and trypsin has proved
effective in the treatment of malignant diseases, and this has
led to the designation of orphan drug status for multiple myeloma
in the USA. WOBE-MUGOS® E aims at the long-term improvement
in the quality of life and reduces the rate of metastases in
breast cancer, colon cancer and multiple myeloma.
How enzymes work
Enzymes act as biocatalysts. They accelerate
and govern all metabolic processes in the body without being
altered themselves.
Our products use enzymes of plant and animal
origin: Bromelain from pineapples, papain form papayas, pancreatin,
trypsin and chymotrypsin from the pancreas of animals. Some
enzyme products also contain rutoside, a plant flavonoid that
seals the blood vessels.
Enzymes have a central importance in ensuring
the equilibrium-between activation and inhibition-of the reactions
of the immune system, which leads to tissue damage in almost
every disease.
A typical vital reaction is inflammation. Enzymes
accelerate the course of such and infection by beneficially
stimulating defense cells, and because they also reduce the
generated swelling, pain and functional impairment.
Enzymes thus promote physiological healthy
processes and contribute to the recovery of the affected tissue.
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